TOTAL SYNTHESIS OF ARDISIAQUINONE A, A POTENT 5-LIPOXYGENASE INHIBITOR, ISOLATED FROM ARDISIA SIEBOLDII, AND DEGREE OF 5-LIPOXYGENASE INHIBITORY ACTIVITY OF ITS DERIVATIVES

Yoshiyasu FUKUYAMA; Yuuko KIRIYAMA; Mitsuaki KODAMA; Hideyuki IWAKI; Shigeki HOSOZAWA; Shinji AKI; Kuniaki MATSUI

doi:10.1248/cpb.42.2211

Yoshiyasu FUKUYAMA, Yuuko KIRIYAMA, Mitsuaki KODAMA, Hideyuki IWAKI, Shigeki HOSOZAWA, Shinji AKI, Kuniaki MATSUI

Author information

Keywords: Ardisia sieboldii, ardisiaquinone A, 1, 4-benzoquinone, 1, 4-benzoquinone synthesis, 5-lipoxygenase inhibitor

JOURNAL FREE ACCESS

1994 Volume 42 Issue 10 Pages 2211-2213

DOI https://doi.org/10.1248/cpb.42.2211

Details

Abstract

Ardisiaquinone A (1), isolated as a potent 5-lipoxygenase inhibitor from the woods of Ardisia sieboldii, has been synthesized efficiently via a cross-coupling reaction between the yne 5 and the iodide 6 derived from the common intermediate 4. Inhibitory activity for 1 and its derivatives is also reported.

Corresponding author

Register with J-STAGE for free!