SYNTHESIS OF 9E- AND 9Z-LOCKED RETINOIC ACID ANALOGS AS LIGANDS FOR RAD AND RXR

Yuko KATSUTA; Yukiko AOYAMA; Hisa OSONE; Akimori WADA; Shimami UCHIYAMA; Takuya KITAMOTO; Shoichi MASUSHIGE; Shigeaki KATO; Masayoshi ITO

doi:10.1248/cpb.42.2659

勝田優子, 青山有希子, 大曽根央, 和田昭盛, 内山至満美, 北本卓也, 舛重正一, 加藤茂明, 伊藤允好

著者情報

キーワード: retinoic acid analog, retinoic acid receptor, retinoic X receptor, transcriptional activity, CAT assay

ジャーナルフリー

1994 年 42 巻 12 号 p. 2659-2661

DOI https://doi.org/10.1248/cpb.42.2659

詳細

抄録

New retinoic acid (RA) analogs 9E-locked-RA 3 and 9Z-locked-RA 4 were synthesized from dithiane 6 and β-cyclocitral 13, respectively. Both analogs behaved as agonistic ligands for a mixture of retinoic acid receptor (RAR) and retinoid X receptor (RXR).

責任著者(Corresponding author)

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