SYNTHESES OF NEW IMMUNOSUPPRESSIVE MYRIOCIN ANALOGS, 2-EPI-MYRIOCIN, 14-DEOXOMYRIOCIN, Z-14-DEOXOMYRIOCIN, AND NOR-DEOXOMYRIOCINS : THEIR STRUCTURE-ACTIVITY RELATIONSHIPS

Masayuki YOSHIKAWA; Yoshihiro YOKOKAWA; Yasuhiro OKUNO; Nobuhiro YAGI; Nobutoshi MURAKAMI

doi:10.1248/cpb.42.2662

吉川雅之, 横川佳浩, 奥野安洋, 矢木信博, 村上啓寿

著者情報

キーワード: myriocin, 2-epi-myriocin, Z-14-deoxomyriocin, nor-deoxomyriocin, immunosuppressive activity, structure-activity relationship

ジャーナルフリー

1994 年 42 巻 12 号 p. 2662-2664

DOI https://doi.org/10.1248/cpb.42.2662

詳細

抄録

Eight new myriocin analogs, 2-epi-myriocin, Z-14-deoxomyriocin, and nor-deoxomyriocins, and a known myriocin derivative, 14-deoxomyriocin, were synthesized from 2-deoxy-D-glucose via common intermediates in previous myriocin and Z-myriocin syntheses. The immunosuppressive activities of new myriocin analogs and Z-myriocin on mouse allogeneic mixed lymphocyte reaction were examined, and, by comparing with those of myriocin and 14-deoxomyriocin, some structure-activity relationships have been found.

責任著者(Corresponding author)

J-STAGEへの登録はこちら（無料）