1994 Volume 42 Issue 9 Pages 1886-1889
An acidic polysaccharide, called cnidirhan SIIB, was isolated from the rhizome of Cnidium officinale MAKINO. It was homogeneous on electrophoresis and gel chromatography, and its molecular mass was estimated to be 7.9×104. It was composed of L-arabinose, D-galactose and D-galacturonic acid in the molar ratio of 9 : 11 : 3, in addition to a few O-acetyl groups. Reduction of carboxyl groups, methylation analysis, nuclear magnetic resonance and controlled Smith degradation studies indicated that its structural features are composed primarily of α-L-arabino-β-3, 6- and 3, 4-branched D-galactan type units. The polysaccharide showed very pronounced reticuloendothelial system-potentiating activity in a carbon clearance test and marked anti-complementary activity.
