Two 1-Alkyl-2-acyl Choline Glycerophospholipids Having an Arachidonoyl or Eicosapentaenoyl Group, from the Clam Worm (Marphysa sanguinea)

Abstract

Ten choline glucerophospholipids (CGP) were isolated from the marine annelid, Marphysa sanguinea. Among them, six compounds were lyso platelet-activating factors (PAFs) and two were 1-hexadecyl-2-arachidonoyl-and 1-hexadecyl-2-eicosapentanoyl-sn-glycero-3-phosphocholines, which are regarded as stored precursor forms of PAF, so-called PAF-like lipid. These two compounds comprised 28% of the alkylacyl CGP fraction and are considered to be the main components of PAF-like lipid in this material.