A Convenient Synthesis of Tertiary Amines by Alkylation of Secondary Amines with Alkyl Halides in the Presence of Potassium Hydride and Triethylamine

Kunihiko MOHRI; Kazumi SUZUKI; Masumi USUI; Kimiaki ISOBE; Yoshisuke TSUDA

doi:10.1248/cpb.43.159

Kunihiko MOHRI, Kazumi SUZUKI, Masumi USUI, Kimiaki ISOBE, Yoshisuke TSUDA

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Keywords: direct N-alkylation, tertiary amine, potassium amide, alkyl halide scavenger, alkyl halide

JOURNAL FREE ACCESS

1995 Volume 43 Issue 1 Pages 159-161

DOI https://doi.org/10.1248/cpb.43.159

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Abstract

N-Alkylation of secondary amines with alkyl halides in the presence of potassium hydride and triethylamine gave corresponding tertiary amines in satisfactory yields.

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