N-COUMARINYL-L-PROLINE, A NOVEL CHIRAL DERIVATIZING AGENT FOR 1H NMR DETERMINATION OF ENANTIOMERIC PURITIES OF ALCOHOLS AND AMINES

Kazuo NAGASAWA; Asami YAMASHITA; Satoru KATOH; Keiichi ITO; Kohji WADA

doi:10.1248/cpb.43.344

N-COUMARINYL-L-PROLINE, A NOVEL CHIRAL DERIVATIZING AGENT FOR ¹H NMR DETERMINATION OF ENANTIOMERIC PURITIES OF ALCOHOLS AND AMINES

Kazuo NAGASAWA, Asami YAMASHITA, Satoru KATOH, Keiichi ITO, Kohji WADA

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Keywords: N-coumarinyl-L-proline, chiral derivatizing agent, ^1H NMR, enantiomeric purity, chiral alcohol, chiral amine

JOURNAL FREE ACCESS

1995 Volume 43 Issue 2 Pages 344-346

DOI https://doi.org/10.1248/cpb.43.344

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Abstract

N-(Coumarin-4-yl)-L-proline[CPRO-1], readily prepared from commercially available Cbz-L-proline and 4-hydroxycoumarin, was proved to be an efficient and useful chiral derivatizing agent by ¹H NMR inspection of the resulting diastereomeric esters and amides.

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