NOVEL FLUOROPROSTACYCLIN ANALOGS WITH MODIFIED CYCLOALKYLENYL CHAINS. HIGHLY POTENT AND ORALLY ACTIVE ANTI-ANGINAL AGENTS

Yasushi MATSUMURA; Tomoyuki ASAI; Toyomichi SHIMADA; Toshiaki NAKAYAMA; Masahiro URUSHIHARA; Yoshitomi MORIZAWA; Aarata YASUDA; Taku YAMAMOTO; Buichi FUJITANI; Kanoo HOSOKI

doi:10.1248/cpb.43.353

Yasushi MATSUMURA, Tomoyuki ASAI, Toyomichi SHIMADA, Toshiaki NAKAYAMA, Masahiro URUSHIHARA, Yoshitomi MORIZAWA, Aarata YASUDA, Taku YAMAMOTO, Buichi FUJITANI, Kanoo HOSOKI

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Keywords: fluoroprostacyclin, anti-anginal activity, platelet aggregation inhibition, hypotensive effect, β-oxidation, iloprost

JOURNAL FREE ACCESS

1995 Volume 43 Issue 2 Pages 353-355

DOI https://doi.org/10.1248/cpb.43.353

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Abstract

Novel fluoroprostacyclin analogs (1a-f) have been synthesized and pharmacologically evaluated. Compounds 1a-c given intravenously or orally showed potent and long-lasting anti-anginal activities in an animal model.

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