NOVEL FLUOROPROSTACYCLIN ANALOGS WITH MODIFIED CYCLOALKYLENYL CHAINS. HIGHLY POTENT AND ORALLY ACTIVE ANTI-ANGINAL AGENTS

Yasushi MATSUMURA; Tomoyuki ASAI; Toyomichi SHIMADA; Toshiaki NAKAYAMA; Masahiro URUSHIHARA; Yoshitomi MORIZAWA; Aarata YASUDA; Taku YAMAMOTO; Buichi FUJITANI; Kanoo HOSOKI

doi:10.1248/cpb.43.353

Yasushi MATSUMURA, Tomoyuki ASAI, Toyomichi SHIMADA, Toshiaki NAKAYAMA, Masahiro URUSHIHARA, Yoshitomi MORIZAWA, Aarata YASUDA, Taku YAMAMOTO, Buichi FUJITANI, Kanoo HOSOKI

Author information

Yasushi MATSUMURA
Tomoyuki ASAI
Toyomichi SHIMADA
Toshiaki NAKAYAMA
Masahiro URUSHIHARA
Yoshitomi MORIZAWA
Aarata YASUDA
Taku YAMAMOTO
Buichi FUJITANI
Kanoo HOSOKI
Author's Organization：
Research Center, Asahi Glass Co., Ltd.,
Research Center, Asahi Glass Co., Ltd.,
Research Center, Asahi Glass Co., Ltd.,
Research Center, Asahi Glass Co., Ltd.,
Research Center, Asahi Glass Co., Ltd.,
Research Center, Asahi Glass Co., Ltd.,
Research Center, Asahi Glass Co., Ltd.,
/ /

Keywords: fluoroprostacyclin, anti-anginal activity, platelet aggregation inhibition, hypotensive effect, β-oxidation, iloprost

JOURNAL FREE ACCESS

1995 Volume 43 Issue 2 Pages 353-355

DOI https://doi.org/10.1248/cpb.43.353

Details

Abstract

Novel fluoroprostacyclin analogs (1a-f) have been synthesized and pharmacologically evaluated. Compounds 1a-c given intravenously or orally showed potent and long-lasting anti-anginal activities in an animal model.

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