Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
SPECIFIC OXIDATION OF RETINOIC ACID TO 4-OXO-RETINOIC ACID IN DILUTED ACID SOLUTIONS
Hideo TANAKA, Hiroyuki KAGECHIKA, Koichi SHUDO
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Keywords: vitamin A, retinoic acid, allylic oxidation, trifluoromethanesulfonic acid
JOURNAL FREE ACCESS

1995 Volume 43 Issue 2 Pages 356-358

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Abstract

Treatment of retinoic acid (1a) or its methyl ester (2a) with hydrochloric acid in methanol gave methyl 4-oxo-retinoates (4a-c). Similar oxidation proceeded when 2a was treated with trifluoromethanesulfonic acid in the presence of lithium chloride in methanol.

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© The Pharmaceutical Society of Japan
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