Fungal Metabolities. XVIII. New Membrane-Modifying Peptides, Trichorozins I-IV, from the Fungus Trichoderma harzianum

Akira IIDA; Masaki SANEKATA; Shun-ichi WADA; Tetsuro FUJITA; Hiromi TANAKA; Akio ENOKI; Goro FUSE; Michiko KANAI; Koji ASAMI

doi:10.1248/cpb.43.392

Akira IIDA, Masaki SANEKATA, Shun-ichi WADA, Tetsuro FUJITA, Hiromi TANAKA, Akio ENOKI, Goro FUSE, Michiko KANAI, Koji ASAMI

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Keywords: Trichoderma harzianum, peptaibol, amino alcohol, α-aminoisobutyric acid, ion channel, trichorozin

JOURNAL FREE ACCESS

1995 Volume 43 Issue 3 Pages 392-397

DOI https://doi.org/10.1248/cpb.43.392

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Abstract

New membrane-modifying peptides, trichorozing I-IV, have been isolated from conidia of the fungus Trichoderma harzianum. Their amino acid sequences were clearly determined by spectrometric methods and, furthermore, they were synthesized by the solution-phase method. Trichorozins are a family of the class of peptaibols and are composed of 11 residues including an amino alcohol. Trichorozins exhibited voltage-dependent ion channel-like activity in lipid bilayers.

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