Scale-Up of Agitation Fluidized Bed Granulation. I. Preliminary Experimental Approach for Optimization of Process Variables

Satoru WATANO; Yoshinobu SATO; Kei MIYANAMI; Takayuki MURAKAMI; Yoshihiro ITO; Tetsuro KAMATA; Nobuhito ODA

doi:10.1248/cpb.43.1212

Satoru WATANO, Yoshinobu SATO, Kei MIYANAMI, Takayuki MURAKAMI, Yoshihiro ITO, Tetsuro KAMATA, Nobuhito ODA

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Keywords: scale-up, granulation, agitation fluidized bed, optimization, operational variable

JOURNAL FREE ACCESS

1995 Volume 43 Issue 7 Pages 1212-1216

DOI https://doi.org/10.1248/cpb.43.1212

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Abstract

Granulation scale-up with an agitation fluidized bed of three sizes (vessel diameter 125, 230, 500 mm) was preliminary investigated. In order to evaluate accurately the scale-up factor on granule properties, process variables such as spray conditions, method for moisture measurement and control, powder feed weight and drying efficiency were optimized.

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