LIPASE-CATALYZED ENANTIOSYNTHESIS OF (R)- AND (S)-2-[BENZYL(PHENYL)AMINO]ETHYL 5-(5, 5-DIMETHYL-2-OXO-1, 3, 2-DIOXAPHOSPHORINAN-2-YL)-1, 4-DIHYDRO-2, 6-DIMETHYL-4-(3-NITROPHENYL)-3-PYRIDINECARBOXYLATE (NZ 105)

Abstract

Homochiral 4-Aryl-1, 4-dihydropyridine-5-phosphate (NZ 105) was synthesized from the racemic materials. The enantioselective hydrolysis by lipase catalyst was smoothly proceeded and optically active carboxylic acid was converted into optically active medicine.