LIPASE-CATALYZED RESOLUTION AND ABSOLUTE CONFIGURATION OF PHOTOPYRIDONES

Hiroto NAKANO; Kazuto IWASA; Chizuko KABUTO; Hisao MATSUZAKI; Hiroshi HONGO

doi:10.1248/cpb.43.1254

Hiroto NAKANO, Kazuto IWASA, Chizuko KABUTO, Hisao MATSUZAKI, Hiroshi HONGO

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Keywords: lipase-catalyzed resolution, chiral photopyridone, lipasePS, lipaseAK, X-ray analysis, CD spectral analysis

JOURNAL FREE ACCESS

1995 Volume 43 Issue 7 Pages 1254-1256

DOI https://doi.org/10.1248/cpb.43.1254

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Abstract

Optically active photopyridones possessing synthetic versatility were obtained conveniently by lipase-catalyzed enantioselective acylation or hydrolysis of racemic photopyridones, and the absolute configurations were determined by chemical correlation, X-ray crystallography and CD spectral analysis.

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