Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
A NEW METHOD FOR THE PREPARATION OF PHENYL-SUBSTITUTED CIS-ENEDIYNE FROM A PHTHALIDE DERIVATIVE
Hisao NEMOTO, Junya KIKUISHI, Masayuki SHIBUYA
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Keywords: DNA, biradical, enediyne, Myers-Saito cyclization
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1996 Volume 44 Issue 11 Pages 2186-2188

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Abstract

Conversion of the phthalide derivative 5 to the enediynes 6 and 11 are described. Treatment of 5 with 1, 8-diazabicyclo[5.4.0]undec-7-ene in hexamethylphosphoric triamide stereoselectively gives 6, which can be used as an efficient DNA-damaging biradical.

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© The Pharmaceutical Society of Japan
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