STERICAL PRORERTIES OF N, N'-DIMETHYLUREA MOIETY ENHANCE FORMATION OF TRIPLY HYDROGEN-BONDED COMPLEXES

Abstract

N, N'-Dimethyl-N, N'-[2-(3-methylureido)pyrid-5-yl]urea (5) was designed and synthesized as a guanylyl-guanosine equivalent molecule. (E)-Perference of the urea bond of 5 enhanced the formation of highly associated complexes of 5 with bis(cytosyl)derivatives.