Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Control Granule Growth in Fluidized Bed Granulation by an Image Processing System
Satoru WATANOYoshinobu SATOKei MIYANAMI
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1996 Volume 44 Issue 8 Pages 1556-1560

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Abstract

In this paper, the control of granule growth in fluidized bed granulation was carried out using a newly developed image processing system. Granule images measured by a particle image probe were digitized by an image processing system during granulation to continuously calculate granule size distribution. To avoid excessive granule growth, fuzzy logic using a linguistic algorithm employing if-then rules with a process lag element taken into consideration was adopted for the control algorithm. This newly developmed system was applied to actual fluidized bed granulation under various powder samples and operating conditions, and the validity of the system was investigated. It was found tha the system could control granule growth with high accuracy, regardless of changes in powder samples and operating conditions.

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© The Pharmaceutical Society of Japan
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