Synthesis and Biological Activities of Optically Active 6-[3-(3, 4-Dimethoxybenzylamino)-2-hydroxypropoxy]-2(1H)-quinolinone (OPC-18790)

Takafumi FUJIOKA; Shuji TERAMOTO; Sachiko TSUJIMI; Kazumi TAKEMOTO; Toyoki MORI; Tetsumi HOSOKAWA; Takumi SUMIDA; Michiaki TOMINAGA; Youichi YABUUCHI

doi:10.1248/cpb.44.1596

Takafumi FUJIOKA, Shuji TERAMOTO, Sachiko TSUJIMI, Kazumi TAKEMOTO, Toyoki MORI, Tetsumi HOSOKAWA, Takumi SUMIDA, Michiaki TOMINAGA, Youichi YABUUCHI

著者情報

キーワード: OPC-18790, optically active epichlorohydrin, cardiotonic agent, 2(1H)-quinolinone, positive inotropic activity

ジャーナルフリー

1996 年 44 巻 8 号 p. 1596-1598

DOI https://doi.org/10.1248/cpb.44.1596

詳細

抄録

The enanitomers of 6-[3-(3, 4-dimethoxybenzylamino)-2-hydroxypropoxy]-2(1H)-quinolinone (OPC-18790), a novel cardiotonic agent, were synthesized and evaluated for positive inotropic activity. The key intermediates, 2, 3-epoxypropoxy derivatives, were obtained by the alkylation of 6-hydroxy-2(1H)-quinolinone with optically active epichlorohydrin and subsequent ring closure.

責任著者(Corresponding author)

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