ALTERNATIVE SYNTHESIS OF DUOCARMYCIN SA USING A TRICYCLIC HETEROAROMATIC INTERMEDIATE PREPARED BY PALLADIUMCATALYZED COUPLING REACTIONS

Abstract

Alternative synthesis of duocarmycin SA (1) was achieved by developing a novel preparation method using palladium catalysts for a tricyclic heteroaromatic compound 4b, followed by transformation into the previously reported intermediates 13 and 14a by way of the alcohol 10b.