INHIBITORY ACTIVITY OF XANTHONE DERIVATIVES ISOLATED FROM SOME GUTTIFERAEOUS PLANTS AGAINST DNA TOPOSIOMERASES I AND II

Hideaki TOSA; Munekazu IINUMA; Toshiyuki TANAKA; Hiroshi NOZAKI; Shougo IKEDA; Ken TSUTSUI; Kimiko TSUTUSI; Masashi YAMADA; Shiho FUJIMORI

doi:10.1248/cpb.45.418

Hideaki TOSA, Munekazu IINUMA, Toshiyuki TANAKA, Hiroshi NOZAKI, Shougo IKEDA, Ken TSUTSUI, Kimiko TSUTUSI, Masashi YAMADA, Shiho FUJIMORI

Author information

Keywords: topoisomerase I, topoisomerase II, Guttiferae, xanthone, subelliptenone F, benzophenone

JOURNAL FREE ACCESS

1997 Volume 45 Issue 2 Pages 418-420

DOI https://doi.org/10.1248/cpb.45.418

Details

Abstract

A xanthone derivative, subelliptenone F, and the related compounds showed an intensive inhibitory effect against topoisomerases I and II in in vitro experiments. These xanthones are prospective lead compounds for anticancer drugs.

Corresponding author

Register with J-STAGE for free!