Cyclokirilodiol and Isocyclokirilodiol : Two Novel Cycloartanes from the Seeds of Trichosanthes kirilowii MAXIM.

Yumiko KIMURA; Toshihiro AKIHISA; Ken YASUKAWA; Sei-ichi TAKASE; Toshitake TAMURA; Yoshiteru IDA

doi:10.1248/cpb.45.415

Yumiko KIMURA, Toshihiro AKIHISA, Ken YASUKAWA, Sei-ichi TAKASE, Toshitake TAMURA, Yoshiteru IDA

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Keywords: Trichosanthes kirilowii, seed, cycloartane triterpene, cyclokirilodiol, isocyclokirilodiol, Cucurbitaceae

JOURNAL FREE ACCESS

1997 Volume 45 Issue 2 Pages 415-417

DOI https://doi.org/10.1248/cpb.45.415

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Abstract

Two novel cycloartane-type triterpene alcohols possessing a monohydroxy-tetrahydrofuran ring in the side chain, cyclokirilodiol and isocyclokirilodiol, were isolated from the nonsaponifiable lipid fraction obtained from the methanolic extract of Trichosanthes kirilowii seeds. Their structures were determined as (22S, 24S)-22, 25-epoxy-24-hydroxy-5α-cycloartan-3β-ol and (22R, 24S)-22, 25-epoxy-24-hydroxy-5α-cycloartan-3β-ol, respectively, by detailed spectroscopic analyses.

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