SYNTHESIS OF A NEW POTENT ANTI-ANGIOGENIC AGENT, 17α-ACETOXY-9α-FLUORO-6α-METHYLPROGESTERONE

Eiichi SUGINO; Shiho FUJIMORI; Satoshi HIBINO; Tominari CHOSHI; Yoshitatsu ICHIHARA; Yoshio SATO; Taketo YAMAJI; Hiroshi TSUBOI; Natsuko MURATA; Masayuki UCHIDA; Mariko SHIMAMURA; Tsutomu OIKAWA

doi:10.1248/cpb.45.421

Eiichi SUGINO, Shiho FUJIMORI, Satoshi HIBINO, Tominari CHOSHI, Yoshitatsu ICHIHARA, Yoshio SATO, Taketo YAMAJI, Hiroshi TSUBOI, Natsuko MURATA, Masayuki UCHIDA, Mariko SHIMAMURA, Tsutomu OIKAWA

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Keywords: 9α-fluoromedroxyprogesterone acetate, synthesis, antiangiogenic activity, anti-cancer agent, angiogenic diseases

JOURNAL FREE ACCESS

1997 Volume 45 Issue 2 Pages 421-423

DOI https://doi.org/10.1248/cpb.45.421

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Abstract

A new anti-angiogenic agent, 17α-acetoxy-9α-fluoro-6α-methylprogesterone (9α-fluoromedoroxyprogesterone acetate [FMPA, 9]) was synthesized in a 10-step sequence. FMPA (9) had about two orders of magnitude stronger antiangiogenic activity than medroxyprogesterone acetate (MPA), as estimated in a bioassay involving chorioallantoic membranes of growing chick embryos.

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