DANSHENOLS A AND B, NEW ALDOSE REDUCTASE INHIBITORS FROM THE ROOT OF SALVIA MILTIORHIZA BUNGE

Rena KASIMU; Purusotam BASNET; Yasuhiro TEZUKA; Shigetoshi KADOTA; Tsuneo NAMBA

doi:10.1248/cpb.45.564

Rena KASIMU, Purusotam BASNET, Yasuhiro TEZUKA, Shigetoshi KADOTA, Tsuneo NAMBA

Author information

Keywords: danshenol, abietane-type diterpene, aldose reductase inhibitor, Salvia miltiorhiza, Lamiaceae

JOURNAL FREE ACCESS

1997 Volume 45 Issue 3 Pages 564-566

DOI https://doi.org/10.1248/cpb.45.564

Details

Abstract

Two new abietane-type diterpenoids, danshenols A (1) and B (2), were isolated from an MeOH extract of Salvia miltiorhiza BUNGE, and their structures determined by chemical and spectroscopic methods including the 2D NMR technique. Danshenol A (1) showed strong inhibitory activity against aldose reductase isolated from the eye lens of rats.

Corresponding author

Register with J-STAGE for free!