TETRAHYDROSWERTIANOLIN : A POTENT HEPATOPROTECTIVE AGENT FROM SWERTIA JAPONICA MAKINO

Koji HASE; Shigetoshi KADOTA; Purusotam BASNET; Jianxin LI; Shuichi TAKAMURA; Tsuneo NAMBA

doi:10.1248/cpb.45.567

Koji HASE, Shigetoshi KADOTA, Purusotam BASNET, Jianxin LI, Shuichi TAKAMURA, Tsuneo NAMBA

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Keywords: Swertia japonica, Gentianaceae, tetrahydroswertianolin, tetrahydroxanthone, D-galactosamine/lipopolysaccharide-induced liver injury

JOURNAL FREE ACCESS

1997 Volume 45 Issue 3 Pages 567-569

DOI https://doi.org/10.1248/cpb.45.567

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Abstract

Tetrahydroswertianolin (1), a new tetrahydroxanthone glycoside, was isolated from the whole plant of Swertia, MAKINO (Gentianaceae). Its structure was determined by chemical and spectroscopic methods including 2D-NMR. This compound was found to be very effective in immunologically induced liver injury in mice.

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