A Facile Copper-Catalyzed Ullmann Condensation : N-Arylation of Heterocyclic Compounds Containing an -NHCO- Moiety

Abstract

N-Aryl heterocyclic compounds were synthesized from aryl halides and heterocyclic compounds containing an -NHCO- moiety by using a catalytic amount (1-10 mol%) of a commercially available copper catalyst in satisfactory yields. This catalytic reaction was applicable to the synthesis of N-aryl-2-pyridone, -2-pyrrolidone, -1(2H)-isoquinolone, -1(2H)-phthalazinone, -4(3H)-quinazolinone and -1, 2, 3-benzotriazin-4(3H)-one derivatives.