Inclusion of Trithia[5]heterohelicene by Various Serum Albumins. An Effective Probe for Chiral Discrimination

Koh-ichi YAMADA; Rieko ISHII; Hiroko NAKAGAWA; Hiroshi KAWAZURA

doi:10.1248/cpb.45.936

Koh-ichi YAMADA, Rieko ISHII, Hiroko NAKAGAWA, Hiroshi KAWAZURA

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Keywords: thiaheterohelicene, induced circular dichroism, serum albumin, chiral discrimination, species specificity

JOURNAL FREE ACCESS

1997 Volume 45 Issue 5 Pages 936-938

DOI https://doi.org/10.1248/cpb.45.936

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Abstract

Recemic 2-hydroxymethyltrithia[5]heterohelicene (2-HT), which has a labile helical structure was incorporated into serum albumins of nine species in 1% ethanolic aqueous solution, giving 1 : 1 complexes which exhibited induced circular dichroism spectra with species specificity. The application of 2-HT to bovine serum as a probe for chiral recognition revealed that the serum itself manifested an apparent chiral discrimination between enantiomers of 2-HT.

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