Studies on Chemical Modification of Monensin. VI. Preparation of C-7 Modified Monensins via Protected 7-Oxomonensin and Evaluation of Their Ion Transport Activity

Abstract

7-Carboxymethylmonensin (3), 7-aminomonensin (4), and 7-oxomonensin (5) were synthesized via protected 7-oxomonensin (2), which is expected to be a useful intermediate for the preparation of various monensin derivatives.Compounds 3-5 exhibited smaller ion transport activity than monensin (1).