Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
Martefragin A, a Novel Indole alkaloid Isolated from Red Alga, Inhibits Lipid Peroxidation
Satoshi TAKAHASHITakayuki MATSUNAGAChika HASEGAWAHaruo SAITODaisuke FUJITAFumiyuki KIUCHIYoshisuke TSUDA
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1998 Volume 46 Issue 10 Pages 1527-1529

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Abstract

Martefragin A (1), a novel indole alkaloid, was isolated from a red alga, Martensia fragilis, by repeated column chromatography. The structure of 1 was elucidated on the basis of spectral analysis of its methyl ester (2), including 1H- and 13C-NMR, 1H-1H correlation spectroscopy (COSY), and 13-1H COSY. A single crystal X-ray analysis of the hydrochloride of 1 confirmed the assignment. Martefragin A (1) showed inhibitory activity on NADPH-dependent lipid peroxidation in rat liver microsomes. The IC50 values of 1, α-tocopherol and ascorbic acid were 2.8, 87 and 200 μM, respectively.

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© The Pharmaceutical Society of Japan
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