Three New Anti-Oxidative Saponarin Analogs from Young green Barley Leaves

Masafumi OHKAWA; Junei KINJO; Yoshihide HAGIWARA; Hideaki HAGIWARA; Hideo UEYAMA; Kazuhiko NAKAMURA; Ryoko ISHIKAWA; Masateru ONO; Toshihiro NOHARA

doi:10.1248/cpb.46.1887

Masafumi OHKAWA, Junei KINJO, Yoshihide HAGIWARA, Hideaki HAGIWARA, Hideo UEYAMA, Kazuhiko NAKAMURA, Ryoko ISHIKAWA, Masateru ONO, Toshihiro NOHARA

Author information

Masafumi OHKAWA
Junei KINJO
Yoshihide HAGIWARA
Hideaki HAGIWARA
Hideo UEYAMA
Kazuhiko NAKAMURA
Ryoko ISHIKAWA
Masateru ONO
Toshihiro NOHARA
Author's Organization：
Faculty of Pharmaceutical Sciences, Kumamoto University
Faculty of Pharmaceutical Sciences, Kumamoto University
Hagiwara Institute of Health
Hagiwara Institute of Health
Japan Pharmaceutical Development Co. Ltd.,
Japan Pharmaceutical Development Co. Ltd.,
Japan Pharmaceutical Development Co. Ltd.,
Faculty of Research Institute of General Education, Kyushu Tokai University
Faculty of Pharmaceutical Sciences, Kumamoto University

Keywords: Horderum vulgare var. nudum, Gramineae, anti-oxidative, flavonoid, isovitexin, saponarin

JOURNAL FREE ACCESS

1998 Volume 46 Issue 12 Pages 1887-1890

DOI https://doi.org/10.1248/cpb.46.1887

Details

Abstract

Three new saponarin analogs, 6'''-sinapoylsaponarin, 6'''-feruloysaponarin and 4'-glucosyl-6'''-sinapoyl-saponarin were isolated together with four known compounds from young green barley (Hordeum vulgare var. nudum) leaves. Their anti-oxidative effects towards superoxide, photo-oxidation of vitamins and the 1, 1-diphenyl-2-picrylhydrazyl radical were tested. The superoxide-scavenging activity depended on the number of free hydroxy groups. In contrast, the inhibition of vitamin oxidation seemed to be due to the flavone skeleton. In addition, the sinapoyl moiety seemed to be important for radical-scavenging activity.

Corresponding author

Register with J-STAGE for free!