Enantio- and Diastereoselective Synthesis of N-[(1R, 2R, 3R, 4R)-2, 3-Diacetoxy-4-(acetoxymethyl)cyclopentyl]acetamide, a Synthetic Key Intermediate of (+)-Cyclaradine

Abstract

Enantio- and diastereoselective synthesis of N-[(1R, 2R, 3R, 4R)-2, 3-diacetoxy-4-(acetoxymethyl)cyclopentyl]-acetamide 1, a synthetic key intermediate of (+)-cyclaradine, has been achieved by using enzyme-catalyzed asymmetric hydrolysis and subsequent modification of a functional group.