Antiproliferative Constituents in Umbelliferae Plants. III. Constituents in the Root and the Ground Part of Anthriscus sylvestris HOFFM.

Abstract

The MeOH extract of the root and the ground part of Anthriscus sylvestris HOFFM. showed a high inhibitory activity against MK-1, HeLa, and B16F10 cell growth in vitro. The activity was found only in the CHCl₃-soluble fractions. From the CHCl₃-soluble fraction of the root, falcarindiol, 1-(3'-methoxy-4', 5'-methylenedioxyphenyl)-1ξ-methoxy-2propene, elemicin, and nemerosin were newly isolated in addition to deoxypodophyllotoxin (anthricin), anthriscusin, (-)-deoxypodorhizone, and anthriscinol methyl ether which were reported earlier as constituents of the root of this plant.From the CHCl₃-soluble fraction of the ground part, deoxypodophyllotoxin, (-)-deoxypodorhizone, nemerosin, and falcarindiol were isolated.In vitro antiproliferative activities of the isolates against MK-1, HeLa, and B16F10 cells are reported.