Antiproliferative Constituents in Umbelliferae Plants. IV. Constituents in the Fruits of Anthriscus sylvestris HOFFM.

Ryuji IKEDA; Tsuneatsu NAGAO; Hikaru OKABE; Yukitaka NAKANO; Hisashi MATSUNAGA; Mitsuo KATANO; Masato MORI

doi:10.1248/cpb.46.875

Ryuji IKEDA, Tsuneatsu NAGAO, Hikaru OKABE, Yukitaka NAKANO, Hisashi MATSUNAGA, Mitsuo KATANO, Masato MORI

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Keywords: Anthriscus sylvestris, Umbelliferae, antiproliferative activity, lignan, phenylpropanoid, polyacetylene

JOURNAL FREE ACCESS

1998 Volume 46 Issue 5 Pages 875-878

DOI https://doi.org/10.1248/cpb.46.875

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Abstract

The constituents in the fruit of Anthriscus sylvestris HOFFM. were investigated, and four ligans [deoxypodophyllotoxin, morelensin, (-)-deoxypodorhizone, and (-)-hinokinin], one phenylpropanoid [1, (3', 4'-dimethoxyphenyl)-1ξ-hydroxy-2-propene], two phenylpropanoid esters [3', 4'-dimethoxycinnamyl (Z)-2-angeloyloxymethyl-2-butenonate and 3', 4'-dimethoxycinnamyl (Z)-2-tigloyloxymethyl-2-butenoate], and one polyacetylenic compound (falcarindiol) were isolated. Their antiproliferative activity against MK-1, HeLa and B16F10 cell lines is reported.

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