Investigation of the Microprecipitation of Folic Acid from Slightly Acidic Injection Solutions Using Dynamic Light Scattering

抄録

Microprecipitation of folic acid was monitored by the dynamic light scattering (DLS) method. The pH was changed by CO₂ absorption and addition of HCl. The folic acid solutions were examined over the pH range 8.5-4.0. Over the pH range 5.4-6.0, microprecipitation was observed and at pH ≤5.2 crude precipitation of folic acid occurred. The dependence of the effective diameter on the pH over the pH range 5.4-6.0 is also reported.