Synthesis of Trimethylhydroquinone Derivatives as Anti-allergic Agents with Anti-oxidative Actions

Abstract

A novel series of trimethylhydroquinone derivatives was synthesized and evaluated for their anti-lipid peroxidation activity in rat liver microsomes, inhibition of rat basophilic leukemia-1 (RBL-1) cell 5-lipoxygenase and 48h homologous passive cutaneous anaphylaxis (PCA) activity in rats. 4-[4-[4-(Diphenylmethyl)-1-piperazinyl]butoxy]-2, 3, 6-trimethylphenol (9c) exhibited the ability to inhibit Fe³⁺-ADP induced NADPH dependent lipid peroxidation (IC₅₀=5.3×10^-7M), 5-lipoxygenase ((IC₅₀=3.5×10^-7M) and PCA reaction (57% inhibition at 100 mg/kg p.o.).