Futalosine and Its Derivatives, New Nucleoside Analogs

Nobuo HOSOKAWA; Hiroshi NAGANAWA; Takako KASAHARA; Seiko HATTORI; Masa HAMADA; Tomio TAKEUCHI; Shinobu YAMAMOTO; Kayoko S. TSUCHIYA; Makoto HORI

doi:10.1248/cpb.47.1032

Nobuo HOSOKAWA, Hiroshi NAGANAWA, Takako KASAHARA, Seiko HATTORI, Masa HAMADA, Tomio TAKEUCHI, Shinobu YAMAMOTO, Kayoko S. TSUCHIYA, Makoto HORI

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Keywords: futalosine, nucleoside analog, HeLa-S3

JOURNAL FREE ACCESS

1999 Volume 47 Issue 7 Pages 1032-1034

DOI https://doi.org/10.1248/cpb.47.1032

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Abstract

Futalosine, a new nucleoside analog, was isolated from a fermentation broth of Streptomyces sp. MK359-NF1. Some chemical derivatives of futalosine were prepared. 6-O-Methylfutalosine methylester inhibited growth of HeLa-S3 cells in vitro (IC₅₀=19.5μg/ml) in contrast to the weak activity of futalosine. 6-O-Methylfutalosine methylester at concentrations higher than 10μg/ml inhibited incorporation of ³H-TdR and ³H-UR but not ³H-Leu into the acid-soluble fractions of HeLa-S3 cells.

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