A Novel β-Glucuronidase Inhibiting Triterpenoid from Paeonia emodi

Abstract

A novel β-glucuronidase inhibiting triterpene (1) has been isolated from the chloroform fraction of Paeonia emodi. Its structure has been established as 1β, 3β, 5α, 23, 24-pentahydroxy-30-norolean-12, 20(29)-dien-28-oic acid on the basis of spectroscopic analysis, including high resolution mass spectroscopy, one and two-dimensional NMR techniques. Oleanolic acid, betulinic acid, ethyl gallate, methyl grevillate and 1, 5-dihydroxy-3-methyl-anthraquinone are also reported for the first time from Paeonia emodi.