Inhibitory Effects of 2'-Hydroxychalcones on Rat Lens Aldose Reductase and Rat Platelet Aggregation

Soon Sung LIM; Sang Hoon JUNG; Jun JI; Kuk Hyun SHIN; Sam Rok KEUM

doi:10.1248/cpb.48.1786

Soon Sung LIM, Sang Hoon JUNG, Jun JI, Kuk Hyun SHIN, Sam Rok KEUM

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Keywords: 5'-chloro-3, 2'-dihydroxychalcone, rat lens aldose reductase, platelet aggregation, diabetic complication

JOURNAL FREE ACCESS

2000 Volume 48 Issue 11 Pages 1786-1789

DOI https://doi.org/10.1248/cpb.48.1786

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Abstract

Inhibitory effects of synthetic 2'-hydroxychalcone derivatives on rat lens aldose reductase (RLAR) and on platelet aggregation were investigated for the prevention or the treatment of chronic diabetic complications. 5'-chloro-4, 2'-dihydroxychalcone (8) and 5'-chloro-3, 2'-dihydroxychalcone (27) exhbited a potent inhibitory effect on rat platelet aggregation induced by ADP (IC₅₀=0.10 and 0.06 mg/ml, respectively) and collagen (IC₅₀=44 and 16 μg/ml, respectively) but showed relatively weak inhibitory activities on RLAR.

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