A New Caffeoly Quinic Acid from Aster scaber and Its Inhibitory Activity against Human Immunodeficiency Virus-1 (HIV-1) Integrase

Hak Cheol KWON; Chil Mann JUNG; Cha Gyun SHIN; Jong Kyo LEE; Sang Un CHOI; Sun Yeou KIM; Kang Ro LEE

doi:10.1248/cpb.48.1796

Hak Cheol KWON, Chil Mann JUNG, Cha Gyun SHIN, Jong Kyo LEE, Sang Un CHOI, Sun Yeou KIM, Kang Ro LEE

著者情報

キーワード: Aster scaber, Asteraceae, caffeoyl quinic acid, (-) 3, 5-dicaffeoyl-muco-quinic acid, HIV-1 integrase

ジャーナルフリー

2000 年 48 巻 11 号 p. 1796-1798

DOI https://doi.org/10.1248/cpb.48.1796

詳細

抄録

The phytochemical study of the aerial parts of Aster scaber THUNB. (Asteraceae) yielded a new caffeoyl quinic acid, (-) 3, 5-dicaffeoyl-muco-quinic acid (2) and three known compounds, (-) 3, 5-dicaffeoyl quinic acid (1), (-) 4, 5-dicaffeoyl quinic acid (3), (-) 5-caffeoyl quinic acid (4). The structures were established by high resolution spectroscopic methods. The antiviral effects against HIV-1 integrase of the compounds was evaluated. (-) 3, 5-Dicaffeoyl-muco-quinic acid (2) exhibited potent antiviral activity with an IC₅₀ value of 7.0±1.3 μg/ml.

責任著者(Corresponding author)

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