Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Isolation of a Potent Anti-MRSA Sesquiterpenoid Quinone from Ulmus davidiana var. japonica
Dong-Yun SHIN, Hwa-Soon KIM, Kyung-Hoon MIN, Soon-Sil HYUN, Soon-Ai KIM, Hoon HUH, Eung-Chil CHOI, Young Hae CHOI, Jinwoong KIM, Seong-Hak CHOI, Won-Bae KIM, Young-Ger SUH
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Keywords: anti-MRSA sesquiterpenoid, Ulmus davidiana var. japonica, mansonone F
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2000 Volume 48 Issue 11 Pages 1805-1806

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Abstract
A highly potent anti-MRSA sesquiterpenoid has been isolated from Ulmus davidiana var. japonica, which has been traditionally used to treat infectious diseases in Korea. This naturally occurring antibiotic was identified as mansonone F (1). This compound has been found to be highly active specifically against MRSA and showed an MIC range of 0.39-3.13 μg/ml which is comparable to that of vancomycin.
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© The Pharmaceutical Society of Japan
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