Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Hydrophobicity Parameters Determined by Reversed-Phase Liquid Chromatography. XIV. Application of a New Hydrogen-accepting Scale of Monosubstituted Pyrazines to Analysis of the Relationship between Octanol-Water Partition Coefficients and Retention Factors Measured in Different Mobile Phases
Chisako YAMAGAMIMiyako HARAGUCHI
Author information
JOURNAL FREE ACCESS

2000 Volume 48 Issue 12 Pages 1973-1977

Details
Abstract
We recently proposed a new H-accepting scale, SHA, for monosubstituted pyrazines, and demonstrated that this parameter works effectively in expressing the relationship between log P (P : 1-octanol/water partition coefficient) and log k' (k' : retention factor derived from reversed phase liquid chromatography) with aqueous methanol solutions as the mobile phase, according to the equation : log k'=α log P+ρσI+sSHA+const., where σI represents the electronic substituent constant. In this work, we have extended the same treatment to analysis of log k' measured in mobile phases containing different organic modifiers such as 1-propanol, acetonitrile, and dioxane, and found that the above equation is still useful. By comparing the correlations obtained, it was confirmed that parameter SHA could be universally utilized for representing the difference in H-bonding effects involved in different partitioning systems.
Content from these authors
© The Pharmaceutical Society of Japan
Previous article Next article
feedback
Top