New Strong Fibrates with Piperidine Moiety

Teruo KOMOTO; Hiroyuki HIROTA; Mari OTSUKA; Jiro KOTAKE; Susumu HASEGAWA; Hidehiko KOYA; Susumu SATO; Takao SAKAMOTO

doi:10.1248/cpb.48.1978

Teruo KOMOTO, Hiroyuki HIROTA, Mari OTSUKA, Jiro KOTAKE, Susumu HASEGAWA, Hidehiko KOYA, Susumu SATO, Takao SAKAMOTO

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Keywords: fibrate, piperidine, hypolipidemic, hypoglycemic

JOURNAL FREE ACCESS

2000 Volume 48 Issue 12 Pages 1978-1985

DOI https://doi.org/10.1248/cpb.48.1978

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Abstract

New fibrates containing piperidine, 4-hydroxypiperidine, piperidin-3-ene, and piperazine moieties in the structures were synthesized and evaluated. Among the synthesized compounds, 2-[3-[1-(4-fluorobenzoyl)-piperidin-4yl]phenoxy]-2-methylpropanoic acid (9aA : AHL-157) showed very superior activities in decreasing triglyceride, cholesterol, and blood sugar compared to bezafibrate in mice and rats.

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