Synthesis of Peptides Mimicking Chemokine Receptor CCR5 and Their Inhibitory Effects against HIV-1 Infection

Koji KONISHI; Kiyoshi IKEDA; Kazuo ACHIWA; Hiroo HOSHINO; Kiyoshi TANAKA

doi:10.1248/cpb.48.308

Koji KONISHI, Kiyoshi IKEDA, Kazuo ACHIWA, Hiroo HOSHINO, Kiyoshi TANAKA

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Keywords: mimicking peptide, anti-HIV-1activity, CPF, sulfation chemokene receptor, hybrid molecule

JOURNAL FREE ACCESS

2000 Volume 48 Issue 2 Pages 308-309

DOI https://doi.org/10.1248/cpb.48.308

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Abstract

Peptides mimicking chemokne receptor CCR5 were synthesized and their anti-HIV-1 activities evaluated. Prepared compounds, especially a sulfated derivatievs, showed significant anti-HIV-1 activities. Furthermore, a hybrid molecule linked to an N-carbomethoxycarbonyl-prolyl-phenylalanine (CPF) moiety had a greater effect.

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