A Novel Cytotoxic C-Methylated Biflavone from the Stem of Cephalotaxus wilsoniana

Yao-Haur KUO; Chin-Hou LIN; Shy-Yuan HWANG; Ya-Ching SHEN; Yi-Ling LEE; Shyh-Yuan LI

doi:10.1248/cpb.48.440

Yao-Haur KUO, Chin-Hou LIN, Shy-Yuan HWANG, Ya-Ching SHEN, Yi-Ling LEE, Shyh-Yuan LI

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Keywords: Cephalotaxus wilsoniana, cytotoxicity, taiwanhomoflavone-A, 6-C-methyl-7, 4'-O-dimethylamentoflavone

JOURNAL FREE ACCESS

2000 Volume 48 Issue 3 Pages 440-441

DOI https://doi.org/10.1248/cpb.48.440

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Abstract

Bioassay-directed fractionation of an ethanolic extract of Cephalotaxus wilsoniana has resulted in the isolation of a novel C-methylated biflavone, taiwanhomoflavone-A (1). Its structure was elucidated on the basis of spectroscopic analysis. Taiwanhomoflavone-A is cytotoxic with ED₅₀ values of 3.4, 1.0, 2.0 and 2.5 μg/ml, respectively, against KB epidermoid carcinoma of nasopharynx, COLO-205 colon carcinoma, Hepa-3B hepatoma, and Hela cervix tumor cells.

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