抄録
Isoquinoline cyclization of N-(3, 4-dimethoxyphenethyl)-2-ethoxycarbonylacetamide and 2-alkyl and 2-dialkyl derivatives was studied. Contrary to expectations, the cyclization of dialkyl-substituted acetamide derivatives proceeded most smoothly with excellent yield of the product. One of such products, ethyl α, α-diethyl-α-(6, 7-dimethoxy-3, 4-dihydro-1-isoquinolyl) acetate, resisted all attempts at dehydrogenation and the starting dihydro base was recovered quantitatively. β-Diethylaminoethyl α, α-diethyl-α-(6, 7-dimethoxy-3, 4-dihydro-1-isoquinolyl) acetate was also prepared for pharmacological evaluation.
