Studies on the Syntheses of Heterocyclic Compounds. XLV. Synthesis of the Methyl Derivatives of Heterocyclic Compounds by the Hydrogenolysis of their Phenylurethans from Primary Alcohol.

Abstract

The methyl derivatives of 2-, 3-, and 4-methylpyridine, 2-methylthiophene, and 2-methylfuran were synthesized from the corresponding primary alcohol by way of its phenylurethan by treating the alcohol with phenyl isocyanate and catalytic hydrogenation of the urethan formed, in the presence of palladium-black and sodium hydroxide.