The Effect of Anti-tumor Agents on the Dehydrogenase Activity of Tumors.

Abstract

The fact was presented in this paper that there was no quantitative parallelism between the tumor-growth retarding effect of a compound on animal tumors and its inhibiting effect on dehydrogenase activity in vitro of the living cells of the same kind of tumor. An attention should therefore be paid to this fact when a drug is to be selected for clinical purpose from the anti-cancer agents by comparing their inhibiting activity on this enzyme of tumor piece taken from a patient.