1958 年 6 巻 6 号 p. 633-638
Several 4-alkoxy-6-methylpyrimidines were prepared and they were derived to N-oxides by the application of hydrogen peroxide in glacial acetic acid solution or monoperphthalic acid in ether. These were all N-monoxides and were derived to corresponding 4-alkoxy-6-methylpyrimidine-2-carbonitrile by the Reissert reaction. The nitriles so obtained were converted to the corresponding acid amides by treatment with alkaline hydrogen peroxide. Treatment of 4-methoxy-6-methylpyrimidine-2-carbonitrile with sodium methoxide afforded 2, 4-dimethoxy-6-methylpyrimidine, confirming the position of cyano group.