On the Reactivity of 2, 6-Dimethyl-pyrimidine-4-carbonitrile.

抄録

Reactivity of cyano group in 4-position of 2, 6-dimethylpyrimidine-4-carbonitrile was examined. This compound behaves like ordinary nitriles in forming 4-acetyl compound with methylmagnesium bromide, 4-carboxylic acid ester with dehydrated alcohol and hydrogen chloride, and 4-acid amide with alkaline hydrogen peroxide. However, it showed specificity in undergoing substitution with methoxyl ion to form 4-methoxy compound. The ester or acid amide obtained by such reaction was reacted with hydrazine hydrate to afford 2, 6-dimethylpyrimidine-4-carbohydrazide. Condensation with few other aldehydes was also carried out.