Studies on the Metabolism of Naturally Occurring Coumarins. V. Urinary Metabolites of Coumarin and Dihydrocoumarin.

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Studies on the metabolic fate of coumarin and dihydrocoumarin have been elucidated. Coumarin was mainly hydroxylated to 3-hydroxycoumarin, umbelliferone, and a trace of 8-hydroxycoumarin. o-Coumaric acid was subjected to opening of the lactone ring and glycine conjugates of o-coumaric acid and melilotic acid were detected in the metabolite. Hydroxylated compounds were conjugated with glucuronic and sulfuric acids. Various metabolites derived from dihydrocoumarin were also detected by paper chromatography. A scheme of metabolic process of coumarin and dihydrocoumarin was also proposed and discussed.