抄録
Optical resolution of 3-piperidino-1, 1-di (2-thienyl)-1-butene hydrochloride and hydrobromide, which had interesting pharmacological properties, was carried out by the preferential recrystallization method, because these could not be resolved by a method for diastereomers. Thus, specific rotation of these isomers was found to be [α]31.5D ±117.8° in ethanol for isomers of hydrochloride and [α]13D ±127.4° in chloroform for those of hydrobromide. Moreover, it was recognized that the racemic modifications of these salts were racemic mixtures and not racemic compounds, by the investigation of the melting point-composition diagrams and infrared absorption spectra.
