Abstract
Harris, et al. synthesized DL-homolysine (IV) by the acetamidomalonate method and obtained its monohydrochloride monohydrate as crystals melting at 176°. (IV) was prepared as its monohydrochloride, m.p. 263°, by the reaction of hydrazoic acid and 1, 1, 6-hexanetricarboxylic acid, which was obtained from cyclohexanone, and (IV) was derived to its benzoate. Two different methods of preparation were further tried, one from 7-aminoheptanoic acid and the other from 1-chloro-5-benzamidopentane, and the same substance melting at 263° was obtained in both cases. The procedure reported by Harris, et al. was followed exactly but the substance of m.p. 263° was obtained instead of that melting at 176° reported by Harris, et al.
